In the prior assessment, squalene has been shown to minimize MPO while increasing HO-step one gene phrase in the human neutrophils and you may monocytes given LPS. MPO are a human necessary protein found mainly within the neutrophil azurophilic granules and you can monocyte lysosomes [85, 86, 87]. The outcome demonstrate that immediately after 18 h of therapy that have 50 M squalene, the brand new mRNA amount of MPO inside LPS-handled individual monocytes and you may neutrophils decreased (P 0.001).

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